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EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
EU RISK ASSESSMENT – DIMETHYL SULPHATE
Short term toxicity to fish
In all studies with aquatic organisms the observed toxicity concerns the toxicity of DMS and its hydrolysis products (methyl sulphate and methanol).
For a static study (temperature 23°C, pH 7.6-7.9, hardness 55 mg/l as CaCO3) with Lepomis macrochirus (33-75 mm) a “best fit” 96-hour LC50 of 7.5 mg/l is reported (Dawson et al., 1977). This value is derived from a concentration-effect range that is considered not reliable. At 7.5 mg/l the survival percentage is 90%. For Leuciscus idus melanotus(1.6-2.6 g, static test, pH 7.5-8.4, hardness 110 mg/l as CaCO3) the LC50is 14 mg/l (Hoechst, 1981).
There are no long-term tests available either for freshwater or marine fish.
In a static test in artificial seawater (salinity not reported, temperature 20°C) with Menidia beryllina the “best fit” 96-hour LC50 is 15 mg/l (Dawson et al., 1977). The behaviour pattern of the marine fish Kuhlia sandvicensis was tested after exposure to DMS at a concentration up to 20 mg/l (Hiatt et al., 1953). Only at the highest dose of 20 mg/l a slight reaction (e.g. mouth movements, vertical swimming) was reported.
Genetic effects were observed in fish embryos following treatment of sperm with DMS and disturbances in the nucleoli of oocytes from fish have been reported following exposure to DMS contaminated water (EHC, 1985).
Acute toxicity to aquatic invertebrates (e.g. Daphnia)
In a study with Daphnia magna, performed according to OECD guidelines, the 48-hour EC50 is 17 mg/l (Hoechst, 1990). No details on test water and test conditions are available.
Toxicity to aquatic plants (e.g. algae)
In a study with Scenedesmus subspicatus, performed according to OECD guidelines (pH 6.1-8.4, temperature 24°C), the 72-hour EC50 for growth rate is 46.9 mg/l (Hoechst, 1988).
Toxicity to microorganisms (e.g. bacteria)
In an activated sludge test, performed according to OECD guidelines (pH 7, temperature 23°C), the 3 hour-EC50 for bacterial respiration inhibition is 377 mg/l (Hoechst, 1990).
In a test for the determination of damage to anaerobic effluent bacteria (fermentation tube method) a toxicity threshold limit of 2000 mg/l is given (Hoechst, 1980). Too little information is available to check the reliability of this test.
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