Registration Dossier

Administrative data

Endpoint:
dermal absorption, other
Remarks:
Mathematical simulation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Data source

Referenceopen allclose all

Title:
IH SkinPerm (v2.04)
Author:
AIHA
Year:
2018
Bibliographic source:
https://www.aiha.org/get-involved/VolunteerGroups/Pages/Exposure-Assessment-Strategies-Committee.aspx
Reference Type:
publication
Title:
Dermal absorption of chemicals: estimation by IH SkinPerm
Author:
Tibaldi R, ten Berge W, Drolet D
Year:
2014
Bibliographic source:
J Occup Environ Hyg.,11(1):19-31

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
IH SkinPerm mathematical tool for estimating dermal absorption

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Entrance data on the test substance :
-temperature : 25°C
-Molecular weight : 472.28
-Vapour pressure : 6.4 x10^-12 Pa
-Water solubility : 0.001 mg/l
-Log kow : 4.73
-Density : 1100 mg/m3
-Melting point : 78 °C

Administration / exposure

Details on in vitro test system (if applicable):
Details of the model used as presented in the attached document.

Results and discussion

Absorption in different matrices:
Details of the results are presented in the attached document.
Percutaneous absorption
Time point:
8 h
Dose:
100
Parameter:
percentage
Absorption:
0 %

Applicant's summary and conclusion

Conclusions:
According to the IH skin perm (QSAR), the dermal absorption of 3,3,5-trimethylcyclohexyl acrylate is 0.1%.