Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-204-8 | CAS number: 10595-49-0
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A NOEC of 0.015 has been calculated for the long-term toxicity of 10595 -49 -0 to fish based on reliable QSAR model results.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.015 mg/L
Additional information
No reliable long-term toxicity data are available for the toxicity of the test substance 10595-49-0 to fish. However, modelled data are available and included in the dossier. Ramboll (2019) undertook a QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program to estimate long-term toxicity to fish. The ECOSAR model estimates aquatic toxicity based on the structural similarity to chemicals for which aquatic studies are available.
3-(dodecanoylamino)-N,N,N-trimethylpropan-1-aminium methyl sulphate (10595-49-0), is a cationic amino quaternary amine surfactant with a methyl sulphate counterion. It is expected to completely dissociate in water at environmentally relevant pH. Consequently, for aquatic toxicity, the two separate ionic constituents are the toxicologically relevant species. The methyl sulphate moiety predominantly behaves as inorganic sulfate ion and its aquatic effects are well understood.
The model was run to determine chronic values (the geometric mean of the NOEC and LOEC) for the cationic amino quaternary amine surfactant (including the 3 separate incorporated QSARs) and the methyl sulphate counterion. The most sensitive chronic value of 0.021 mg/l was derived for fish based on the amide component of the cationic amino quaternary amine surfactant. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value, by dividing the ChV by √2. This provides a calculated NOEC = 0.015 mg/L for the amide category and consequently will be taken for the long-term toxicity to fish endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
