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EC number: 266-417-7 | CAS number: 66587-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions, not carried out to GLP but subject to QA audit.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Method: other: in house protocol
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C6-12
- EC Number:
- 271-642-9
- EC Name:
- Alcohols, C6-12
- Cas Number:
- 68603-15-6
- IUPAC Name:
- octan-1-ol
- Details on test material:
- Tradename Linevol 79, C6-12 alcohols Type C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: hell Toxicology Laboratory (Tunstall) Breeding Unit, Sittingbourne, Kent, UK
- Age at study initiation: 11 weeks approx.
- Housing: After exposure the animals were individually housed in hanging polypropylene cages with stainless steel wire mesh floor and top. They were mounted in rows of four, with forty cages on each double sided rack.
- Diet: rat food, ad libitum
- Water: filtered but untreated water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 20
- Humidity (%): ca. 55
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: atmosphere generated as a mist
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 7 litres
- Method of holding animals in test chamber: stainless steel mesh carriers
- Source and rate of air: the test atmosphere was apssed through each of the chambers at minimal flow rate of 10 l/min
- System of generating particulates/aerosols: The test atmosphere was generated as a mist using a Sonicore ultrasonic atomiser fitted with a number 035 nozzle. The test substance was supplied to the atomiser at a constant flow rate using a pressure pump and the compressed air was supplied through a Fisher pressure controller.
- Method of particle size determination: The particle size distribution was determined using a Casella four stage impactor.
TEST ATMOSPHERE
- Brief description of analytical method used: the test atmosphere was analysed gravimetrically throughout the exposure period in consecutive periods in 30 min.
TEST ATMOSPHERE (if not tabulated)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 3.4 um / 1.5 - Duration of exposure:
- 4 h
- Concentrations:
- 0.58 mg/l
- No. of animals per sex per dose:
- 5M, 5F
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs observed throughout exposure and daily thereafter throughout the 14 day observation period. Initial and terminal bodyweights were recorded.
- Necropsy of survivors performed: yes/no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.58 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: During the exposure period 50% of the rats salivated and a red nasal discharge was observed. These signs had disappeared by the following day.
- Body weight:
- Body weight data was not reported.
- Gross pathology:
- Not carried out.
- Other findings:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The rat 4 hour LC50 for a mist of Linevol 79 is >0.58 mg/l. Signs of intoxication were transient and confined to salivation and red nasal discharge in some rats during exposure.
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