Registration Dossier
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EC number: 605-617-4 | CAS number: 17183-98-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- pre-guideline study
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- (1R,3aS,3bR,9S,9aS,9bS,11aS)-1-acetyl-5-chloro-9-(chloromethyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
- EC Number:
- 605-617-4
- Cas Number:
- 17183-98-1
- Molecular formula:
- C24 H30 Cl2 O4
- IUPAC Name:
- (1R,3aS,3bR,9S,9aS,9bS,11aS)-1-acetyl-5-chloro-9-(chloromethyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 2000 mg/kg (application volume 10 ml/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No animal died in the course of the study.
No compound-related clinical findings were observed. The body weight gain observed on day 7 and day 14 was within or slightly above the normal range for rats (M+F) of the age and strain which were routinely used in the study laboratory.
No abnormalities were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is of low oral toxicity.
- Executive summary:
The single oral administration of the test substance (ZK 10882) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs were observed and there were no macroscopic pathological signs.
The LD50 acute oral toxicity of 6 -Chlor-Chlormethyldien in rats is therefore above 2000 mg/kg body weight.
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