Registration Dossier
Registration Dossier
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EC number: 939-575-6 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
Although no specific carcinogenicity study is available on alkyl ether sulfates (AES), the scientific weight of the evidence suggests that members of the AES category do not cause carcinogenic effects. This expert judgment takes account of the complete absence of genotoxicity and structural alerts for genotoxicity and carcinogenicity for all members of AES category as well as their overall low toxicity in repeated dose toxicity studies.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on weight of evidence members of the AES category does not cause carcinogenicity. This endpoint is therefore considered to be conclusive but not sufficient for classification.
Additional information
The alkyl ether sulfates (AES) reported within the category show similar structural, physico-chemical, environmental and toxicological properties. The approach of grouping different AES for the evaluation of their effects on human health and the environment was also made by the Danish EPA (2001) and HERA (2003), supporting the read-across approach between structurally related AES.
Several studies investigating the genetic toxicity of different AES in vitro and in vivo have shown that AES are not genotoxic. Moreover, the repeated dose toxicity tests revealed no substance-related adverse effects indicative for carcinogenicity such as preneoplastic lesions (e.g. hyperplasia or metaplasia). Furthermore, AES are metabolised to physiologically occurring metabolites, which chemically behave like in the same way as their natural counterparts. The systemic toxicity of the compounds in this category is predicted to be very low, based on the known properties of the predictable metabolites. Based on this weight of evidence approach members of the AES category does not cause carcinogenicity. In accordance to Regulation (EC) No. 1907/2006, Annex X, 8.9.1 Column 2, testing of carcinogenicity is not required.
References:
Danish EPA - Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products (2001). Environmental Project No. 615, pp. 24-28
HERA (2003). Human & Environmental Risk Assessment on ingredients of European household cleaning products Alcohol Ethoxysulphates, Human Health Risk Assessment Draft, 2003. http: //www. heraproject. com.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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