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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The repeated toxicity was investigated with a Sub-chronic (13 week) oral toxicity study in rats following the FDA guideline for testing food addtives (Toxicological Principles for the Safety Assessment of Direct Food Additives and Colour additives used in food; US Food and Drug Administration Bureau of Foods, 1982). The study was performed in GLP.
20 females and 20 males per dose group were treated at the following doses: 5, 13 and 24 mg/kg b.w.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
24 mg/kg bw/day
Study duration:

Additional information

The dietary administraion of UVASORB HA88 for 13 weeks to rats did not cause any changes nasopharynx, lungs, mediastinal lumph nodes, liver and meenteric lymph nodes. No test substance particles were encountered in any organ examined. Also, in none of these organs foreign body reaction was seen.

Justification for classification or non-classification

Basing on the results above reported, REGULATION (EC) No 1272/2008 (EU Regulation on Classification, Labelling and Packaging of substances and mixtures) would indicate the following:


Repeated Toxicity

Classification : Not classified

Signal word : -

Hazard statement (Oral) : -