N-butyl-2,2,6,6-tetramethylpiperidin-4-amine, oligomeric reaction products with N,N'-bis(3-aminopropyl)ethylenediamine and 2,4,6-trichloro-1,3,5-triazine

Endpoint summary

Additional information

Uvasorb HA88 did not induce a significant increase in the number of reversions, both in absence and in presence of metabolic activation, in TA 1535, TA 1537, TA 1538, TA 98 and TA 100 Salmonella typhimurium strains, in a duplicate experiment.

The test substanced did not induce mutation at the HGPRT locus of the CHO cells and it is considered not clastogenic under the conditions of the chromosomal aberration assay.

Short description of key information:
The following studies are available to asses the genetic toxicity of Uvasorb HA88:
- Ames test in strains of Salmonella Typhimurium, according OECD 471 (Bacterial Reverse mutation Assay);
- In vitro assay for the induction of point mutations at the HGRPT-locus of chinese hamster ovary cells, according OECD 476 (In vitro Mammalian Cell Gene Mutation Test);
- Chromosome analysis of Chinese hamster ovary cells treated in vitro, according OECD Guideline 473 (In vitro Mammalian Chromosome Aberration Test).

All studies were performed in GLP compliance.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Basing on the results above reported, REGULATION (EC) No 1272/2008 (EU Regulation on Classification, Labelling and Packaging of substances and mixtures) would indicate the following:

 

Genetic Toxicity

Classification : Not classified

Signal word :

Hazard statement (Oral) :