Tetrakis(tritolyl phosphite )nickel

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

3 November - 16 December 1983

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: comparable to guidelines/standards.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Principles of method if other than guideline:

Acute Skin Absorption LD50 Test on Rabbits

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrakis(tritolyl phosphite )nickel

EC Number:

252-777-2

EC Name:

Tetrakis(tritolyl phosphite )nickel

Cas Number:

35884-66-3

Molecular formula:

C84H84NiO12P4

IUPAC Name:

tetrakis(tris(4-methylphenyl) phosphite) nickel

Details on test material:

- Name of test material (as cited in study report): Nickel, tetrakis[tris(3-methyl-phenyl) phosphite-P]-, mixture with tetrakis[tris(4-methylphenyl)phosphite-P]nickel

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

No data.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

See below.

Duration of exposure:

24 h

Doses:

1000, 1500, 2000 mg/kg bw

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

The LD50 value was calculated from mortality data, using the method of D. J. Finney:
Finney, D. J., Probit Analysis, 3rd Ed., 1971, Cambridge University Press.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

1 129 mg/kg bw

Based on:

test mat.

95% CL:

>= 613 - <= 1 424

Remarks on result:

other: (corresponding to 508 mg/kg bw for the submission substance)

Mortality:

See table below. All deaths occurred within 2 days after dosing.

Clinical signs:

other: Prostration at 1500 and 2000 mg/kg.

Any other information on results incl. tables

Dose as received         Average wt (g)              

Sex No.     mg/kg     Avg. mL            Initial       14 Days       Mortality     (mg/kg)

Male   6    2000        5.05                   2776          -                      6/6        1129

6    1500        3.20                   2344         2625                  5/6

6     1000        2.06                  2257         2631                  2/6

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Single dermal application of the test material caused lethality in male rabbits, resulting in an LD50 of 1129 mg/kg bw (corresponding to 508 mg/kg bw submission substance only).

Executive summary:

The test substance was subject to an acute dermal LD50 test on rabbits. Doses of 1000 to 2000 mg/kg were applied to intact skin under occlusive conditions for 24 hours. Deaths occured in all dose groups within 2 days after dosing. The LD50 is 1129 mg/kg bw, corresponding to 508 mg/kg bw for the submission substance only.