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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Administrative data

Description of key information

Data and assessment from CaSO4 according to justification for read across (see separate document in iuclid chapter 13). 
Calcium sulfate has been shown to be non-genotoxic both in vitro and in vivo. These observations indicate that calcium sulfate is not expected to be a genotoxic carcinogen. Calcium sulfate has been examined in repeat dose oral studies and has shown low levels of toxicity. There is sufficient data to indicate that calcium sulfate does not pose a risk of carcinogenicity.

Key value for chemical safety assessment

Justification for classification or non-classification

No classification is warranted under DSD or CLP for carcinogenicity based on evidence from genotoxicity and repeat dose studies.

Additional information

There are no lifetime animal studies available on calcium sulfate in order to directly investigate for possible carcinogenic activity. However, calcium sulfate gave negative results in the in vitro and in vivo genotoxicity studies. In repeat dose studies with calcium sulfate there is no evidence that calcium sulfate is able to induce hyperplasia or pre-neoplastic lesions.