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EC number: 204-018-1 | CAS number: 112-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 20th October 2008 to 24th November 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented guideline study
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 306 (Biodegradability in Seawater)
- Deviations:
- yes
- Remarks:
- Ammonium chloride was omitted from the medium to prevent oxygen consumption due to nitrification, and the oxygen consumption was measured at day 0, 7, 14 and 28 instead of day 5, 15 and 28.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No surrogate or analogue material - Radiolabelling:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water
- Details on source and properties of surface water:
- Seawater was collected from coastal water near the Oosterscheldedam (Banjaard, The Netherlands) at high tide (20-10-2008). The seawater was sampled approximately 10 cm below the water surface. The temperature of the water was 14.3°C. The seawater was aged to reduce the concentration of biodegradable compounds present in the seawater. To this end, the seawater was aerated for 7 days at room temperature in diffused light.
- Details on source and properties of sediment:
- No sediment
- Details on inoculum:
- No inoculum: natural population from the seawater
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 1 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Natural sea water + added nutrients:
KH2PO4 8.5 mg/L
K2HPO4 21.75 mg/L
Na2PO4 . 2H20 33.3 mg/L
MgSO4.7H20 22.5 mg/L
CaCl2 27.5 mg/L
FeCl3.6H2O 0.25 mg/L
Ammonium was omitted from the medium to prevent nitrification.
- Solubilising agent (type and concentration if used): silicone oil AR 20 (1 mL/L test medium)
- Test temperature: 18 +/- 2°C
- pH: 7.6
- pH adjusted: no
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 0.30 L BOD bottles with glass stoppers
- Number of culture flasks/concentration:
10 bottles containing seawater and silicone oil
10 bottles containig the test substance (1.0 mg/L) in silicone oil and seawater
10 bottles containing sodium acetate (6.7 mg/L) and seawater
10 bottles containing only seawater
- Measuring equipment: see above §"details on analytical methods"
- Test performed in closed vessels due to significant volatility of test substance: yes
SAMPLING
- Sampling frequency: every week (7, 14, 21 and 28 days)
- Sampling method: two duplicate bottles of all series were withdrawn for analyses of the dissolved oxygen concentration at each sampling time - Reference substance:
- acetic acid, sodium salt
- Remarks:
- 6.7 mg/L
- Test performance:
- The validity of the test is demonstrated by an endogenous respiration of 1.0 mg/L at day 28. The blank respiration therefore does not exceed 30% of the oxygen in the test bottles. Sodium acetate was degraded 85% of its ThOD after 28 days. The validity of the test is also shown by oxygen concentrations >0.5 mg/L in all bottles during the test period.
- Compartment:
- other: water, material (mass) balance
- % Recovery:
- 100
- Compartment:
- other: sediment, material (mass) balance
- % Recovery:
- 0
- Key result
- % Degr.:
- 74
- Parameter:
- O2 consumption
- Sampling time:
- 28 d
- Transformation products:
- not specified
- Details on transformation products:
- No details
- Details on results:
- See § Any other information below.
- Results with reference substance:
- Biodegradation of the reference substance was 85% at day 28.
- Validity criteria fulfilled:
- yes
- Conclusions:
- DEV 2008-016 is degraded 74% at 28 days. It is therefore considered readily biodegradable.
- Executive summary:
In order to assess the biotic degradation in seawater, a biodegradability test according to OECD TG 306 was performed. The biodegradability was determined in the Closed Bottle test performed according to slightly modified OECD Test Guidelines, and in compliance with the OECD principles of Good Laboratory Practice.
DEV 2008 -016 did not cause a reduction in the endogenous respiration. The test substance is therefore considered to be non-inhibitory to the inoculum. DEV 2008 -016 was biodegraded 74% at day 28 in the Closed Bottle test. Hence this substance should be classified as readily biodegradable.
The test is valid as shown by an endogenous respiration of 1.0 mg/L and by the total mineralisation of the reference compound, sodium acetate. Sodium acetate was degraded 85% of its theoretical oxygen demand after 28 days. Finally, the most important criterion was met by oxygen concentrations >0.5 mg/L in all bottles during the test period.
Reference
Table 1. Dissolved oxygen concentrations (mg/L) in the closed bottles.
Time (days) |
Oxygen concentration (mg/L) |
|||
Oco |
Ot |
Oc |
Oa |
|
0 |
7.1 |
7.1 |
7.1 |
7.1 |
7.1 |
7.1 |
7.1 |
7.1 |
|
Mean (M) |
7.1 |
7.1 |
7.1 |
7.1 |
7 |
6.9 |
5.2 |
6.8 |
2.7 |
6.7 |
4.8 |
6.9 |
2.6 |
|
Mean (M) |
6.8 |
5.0 |
6.9 |
2.7 |
14 |
6.5 |
4.2 |
6.5 |
2.0 |
6.4 |
4.3 |
6.4 |
2.0 |
|
Mean (M) |
6.5 |
4.3 |
6.5 |
2.0 |
21 |
6.1 |
3.9 |
6.0 |
1.5 |
6.1 |
3.8 |
6.1 |
1.4 |
|
Mean (M) |
6.1 |
3.9 |
6.1 |
1.5 |
28 |
6.0 |
3.5 |
6.1 |
1.5 |
6.1 |
3.5 |
6.1 |
1.4 |
|
Mean (M) |
6.1 |
3.5 |
6.1 |
1.5 |
Oco = Seawater (inoculum) with mineral nutrient solution, with 0.3 mL of silicone oil but without test material.
Ot = Seawater (inoculum) with mineral nutrient solution with test material in silicone oil (1.0 mg/L).
Oc = Seawater (inoculum) with mineral nutrient solution but without test material and reference substance.
Oa= Seawater (inoculum) with mineral nutrient solution with sodium acetate (6.7 mg/L).
Table 2. Oxygen consumption (mg/L) and the percentages biodegradation (BOD/ThOD) of DEV 2008-016 and sodium acetate in the closed bottle test inoculated with seawater
Time (days) |
Oxygen consumption (mg/L) |
Biodegradation (%) |
||
Test |
Acetate |
Test |
Acetate |
|
0 |
0.0 |
0.0 |
0 |
0 |
7 |
1.8 |
4.2 |
51 |
78 |
14 |
2.2 |
4.5 |
63 |
83 |
21 |
2.2 |
4.6 |
63 |
85 |
28 |
2.6 |
4.6 |
74 |
85 |
Description of key information
There is no data available for this substance. However, key data is available for structural analogue, Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics and presented in the dossier. The data is read across to this substance based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Biodegradation in seawater: Several studies conducted according to OECD 306 guideline were available and all concluded to the ready biodegradability of Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics in seawater according to OECD criteria for biodegradability in seawater.
Biodegradation in sediment: Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics are readily biodegradable. Therefore, in accordance with REACH Annex IX column 2 exemption, the simulation testing in sediment does not need to be conducted.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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