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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from computational model developed by USEPA
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Effect of test chemical on daphnia magna was predicted usimg the ECOSAR v1.1
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
Common name: Water flea
Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
17 475.27 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
immobilisation
Remarks on result:
other: ECOSAR v1.11
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of effects observed in a flow through freshwater system, the NOEC value for the substance is estimated to be 17475.27 mg/l for aquatic invertebrate for 21 days of exposure duration.
Executive summary:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrate was predicted for test substance . On the basis of effects observed in a semi static freshwater system, the NOEC value for the test substance is estimated to be 17475.27 m g/l for aquatic invertebrate for 21 days of exposure, Based on the NOEC value it can be concluded that the test chemical cannot be classified as per the CLP classification criteria.

Description of key information

Based on the EPI Suite ECOSAR version 1.10 predicted model, In 21 days long term aquatic invertebrates toxicity i.e NOEC value was estimated to be 17475.27 mg/l to Daphnid on the basis of reproductive effects.This estimated NOEC value indicate that test substance is non toxic to Daphnia magna.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
17 475.27 mg/L

Additional information

Based on the EPI Suite ECOSAR version 1.10 predicted model, In 21 days long term aquatic invertebrates toxicity i.e NOEC value was estimated to be 17475.27 mg/l to Daphnid on the basis of reproductive effects.This estimated NOEC value indicate that test substance is non toxic to Daphnia magna.