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Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data for various test chemicals
Justification for type of information:
experimental data for various test chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: Refer the principles below
Principles of method if other than guideline:
WoE report is prepared based on toxicity to microorganisms study:
2 and 3 reports
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: 2: Chilomonas paramaecium 3: Pseudomonas putida
Test type:
static
Water media type:
not specified
Limit test:
no
Total exposure duration:
48 h
Remarks on exposure duration:
3rd study exposure was for 16 hours.
Reference substance (positive control):
no
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2 774 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Decrease in the cell count
Key result
Duration:
16 h
Dose descriptor:
other: TT
Remarks:
thresold toxicity
Effect conc.:
255 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
not specified
Conclusions:
2:The effects of test chemical on the chilomonas paramecium was studied and the median effective concentration was determined to be 2774 mg/L.
3: The effect of the test chemical on their cell multiplication was studied for the 16.0 h and thresold toxicity was determined to be 255 mg/L.
Executive summary:

The weight of evidence was prepared by taking the read across of structurally and functionally similar structure.

The data was published in the peer reviewed journal.

The study outlines the effects of test chemical on the test species chilomonas paramecium. The test was performed for the period of 48 hours in the static exposure conditions. Based on the outcome the median lethal concentration of test chemical was 2774mg/L.

Similar study outlines the effects of test chemical on the test species Pseudomonas putida. The basis of effect was their cell multiplication for the period 16.0 h and threshold toxicity was determined to be 255 mg/L.

Thus based on the outcomes the test chemical is toxicity ranges between 255- 2774 mg/L to various microorganisms.

Description of key information

The study outlines the effects of test chemical on the test species chilomonas paramecium. The test was performed for the period of 48 hours in the static exposure conditions. Based on the outcome the median lethal concentration of test chemical was 2774mg/L.

 

Key value for chemical safety assessment

EC50 for microorganisms:
2 774 mg/L

Additional information

The weight of evidence was prepared by taking the read across of structurally and functionally similar structure.

The data was published in the peer reviewed journal.

The study outlines the effects of test chemical on the test species chilomonas paramecium. The test was performed for the period of 48 hours in the static exposure conditions. Based on the outcome the median lethal concentration of test chemical was 2774mg/L.

Similar study outlines the effects of test chemical on the test species Pseudomonas putida. The basis of effect was their cell multiplication for the period 16.0 h and threshold toxicity was determined to be 255 mg/L.

Thus based on the outcomes the test chemical is toxicity ranges between 255- 2774 mg/L to various microorganisms.