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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The only study available was not selected as a key study since only an abstract was available (Frank, 1968). In this dermal sensitization study, 3-Pentenenitrile (purity unknown) was tested in male albino guinea-pigs. Undiluted 3-Pentenenitrile was tested by epicutaneous or intradermal induction. Five guinea pigs received 9 applications of undiluted test substance, and five others received 4 intradermal injections (each 0.1 mL of 0.85% solution in dimethyl phthalate). A 2 week rest period was followed by a challenge test consisting of applications of 100% test substance and 43% solution in 1:1 acetone-dioxane containing 13% guinea pig fat (f.a.d.) to both intact and abraded skin.

Mild erythema was observed on day 1 on some animals but no sensitization was noted on day 2.


Migrated from Short description of key information:
No key study can be identified. However, in one available abstract (Frank, 1968), (Kr: 3), 3-Pentenenitrile did not induce skin sensitization on male

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data

Justification for classification or non-classification

3-Pentenenitrile is not classified as skin sensitizer according to the EU legislation (Directive 67/548/EEC and Regulation 1272/2008/EC).