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Toxicity to microorganisms

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Description of key information

Key value for chemical safety assessment

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Read across justification

Several criteria justify the use of the read across approach to fill data gaps for foots oils using other lubricant base oil analogs. Primarily the basis for the read-across is the similar physical chemical properties shared by the foots oils and other lubricant base oils.

Short-term toxicity to microorganisms has been filled by read-across of measured data from other lubricant base oils. It is supported in a weight of evidence approach by a calculated value using composition information derived from two dimensional gas chromatography in conjunction with the PETROTOX model.

In a read-across key static 4-day Photobacterium phosphoreum luminescence inhibition study (KS=2) using other lubricant base oils as control substances, no significant luminescence inhibition was observed for Spindle oil (BP 320-400 ºC) and Neutral oil Ro NIII (BP 400-450 ºC), as well as for the n-paraffin dodecane. The actual NOEL for Spindle oil was > 1.93 mg/L and the actual NOEL for Neutral oil Ro NIII was > 2.17 mg/L (Riis et al., 1996).

The results of computer modelling to estimate aquatic toxicity show no acute toxicity of foots oil to aquatic microorganisms at or below its maximum attainable water solubility (Redman et al., 2010b). This supports the Riis et al. 1996 experimental results mentioned in the previous paragraph.

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