Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Remarks:
Estimated by calculation: internationally accepted method
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Internationally accepted method, EPI-Suite EPA (USA)
Principles of method if other than guideline:
EPI-Suite KOWWIN v1.69 estimate
GLP compliance:
no
Type of method:
other: estimated by calculation
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
9.78
Remarks on result:
other: KOWWIN v1.69 estimate

Estimated by calculation. No data provided on the temperature or pH.

Conclusions:
Log Pow EPISUITE = 9.78 (KOWWIN v1.69 estimate)
Executive summary:

Log Pow EPISUITE = 9.78 (KOWWIN v1.69 estimate)

Description of key information

Data waiving: Study technically not feasible.

Standard tests for this endpoint are intended for single substances and are not appropriate for this complex substance.

The different components of multiconstituent substances have different behaviour in the physico-chemical tests and therefore also in vivo and in the environment. It is therefore important to ensure that the results presented for the physico-chemical tests represent each

component rather than the mixture being treated as a single component. Therefore, the individual value for the main component partition coefficient (log Pow) is presented :

Estimated value for the main component of the substance:

Log Pow EPISUITE = 9.78 (KOWWIN v1.69 estimate)

Key value for chemical safety assessment

Log Kow (Log Pow):
9.78

Additional information

Data waiving: Study technically not feasible.

Standard tests for this endpoint are intended for single substances and are not appropriate for this complex substance.

The different components of multiconstituent substances have different behaviour in the physico-chemical tests and therefore also in vivo and in the environment. It is therefore important to ensure that the results presented for the physico-chemical tests represent each

component rather than the mixture being treated as a single component. Therefore, the individual values for the partition coefficient (log Pow) are presented:

Main component 1:

Log Pow EPISUITE = 9.78 (KOWWIN v1.68 estimate)

Main component 2:

Log Pow EPISUITE = 7.19 (KOWWIN v1.68 estimate)

Categories Display