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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: secondary source
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source; the orginal references were not available; the data are summarized and published in the document "Thiourea [MAK Value Documentation, 1990]

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Thiourea
Author:
MAK
Year:
1990
Bibliographic source:
The MAK Collection for Occupational Health and Safety. 302–314.
Reference Type:
publication
Title:
no data
Author:
Danowsiri, T. S. et al.
Year:
1948
Bibliographic source:
Amer. J. med. Sci. 215, 123 (1948)
Reference Type:
publication
Title:
Minimum dosage of thiourea, given together with iodine medication, necessary for the production amd maintenance of a remission in hyperthyroidism
Author:
Winkler, A. W. et al.
Year:
1947
Bibliographic source:
Journal of Clinical Investigation, 26:446–452.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
other: no specific endpoint is addressed
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The treatment of excessive thyroid gland activity with different doses of thiourea is discussed.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
no details are available

Method

Type of population:
general
Subjects:
no data
Ethical approval:
not specified
Route of exposure:
other: no data
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
Patients with excessive thyroid gland activity were treated with different doses of thiourea. Different doses were used: 2-3 g daily as initial dose; 75-210 mg daily for the first 4 - 8 weeks of therapy; an initial dose of 15-75 mg; a daily dose of 25-70 mg.
Examinations:
no data
Medical treatment:
no data

Results and discussion

Clinical signs:
Daily dose of 2-3 g: gastrointestinal disorders; An initial dose of 15–75 mg was not reliably effective; A dose of 25–70 mg daily was recommended for the subsequent continuous therapy for which 10–15 mg were ineffective; 10 mg administered daily is said to be insufficient to depress thyroid activity
Results of examinations:
no details are available
Effectivity of medical treatment:
no data
Outcome of incidence:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Conclusions:
A dose of 25–70 mg daily was recommended for the subsequent continuous therapy for which 10–15 mg were ineffective. Thus 10 mg administered daily is said to be insufficient to depress thyroid activity in humans.