Registration Dossier
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EC number: 200-543-5 | CAS number: 62-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: secondary source
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source; the orginal references were not available; the data are summarized and published in the document "Thiourea [MAK Value Documentation, 1990]
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Thiourea
- Author:
- MAK
- Year:
- 1 990
- Bibliographic source:
- The MAK Collection for Occupational Health and Safety. 302–314.
- Reference Type:
- publication
- Title:
- no data
- Author:
- Danowsiri, T. S. et al.
- Year:
- 1 948
- Bibliographic source:
- Amer. J. med. Sci. 215, 123 (1948)
- Reference Type:
- publication
- Title:
- Minimum dosage of thiourea, given together with iodine medication, necessary for the production amd maintenance of a remission in hyperthyroidism
- Author:
- Winkler, A. W. et al.
- Year:
- 1 947
- Bibliographic source:
- Journal of Clinical Investigation, 26:446–452.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- other: no specific endpoint is addressed
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The treatment of excessive thyroid gland activity with different doses of thiourea is discussed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Thiourea
- EC Number:
- 200-543-5
- EC Name:
- Thiourea
- Cas Number:
- 62-56-6
- Molecular formula:
- CH4N2S
- IUPAC Name:
- thiourea
- Test material form:
- not specified
- Details on test material:
- no details are available
Constituent 1
Method
- Type of population:
- general
- Subjects:
- no data
- Ethical approval:
- not specified
- Route of exposure:
- other: no data
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- Patients with excessive thyroid gland activity were treated with different doses of thiourea. Different doses were used: 2-3 g daily as initial dose; 75-210 mg daily for the first 4 - 8 weeks of therapy; an initial dose of 15-75 mg; a daily dose of 25-70 mg.
- Examinations:
- no data
- Medical treatment:
- no data
Results and discussion
- Clinical signs:
- Daily dose of 2-3 g: gastrointestinal disorders; An initial dose of 15–75 mg was not reliably effective; A dose of 25–70 mg daily was recommended for the subsequent continuous therapy for which 10–15 mg were ineffective; 10 mg administered daily is said to be insufficient to depress thyroid activity
- Results of examinations:
- no details are available
- Effectivity of medical treatment:
- no data
- Outcome of incidence:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- A dose of 25–70 mg daily was recommended for the subsequent continuous therapy for which 10–15 mg were ineffective. Thus 10 mg administered daily is said to be insufficient to depress thyroid activity in humans.
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