Registration Dossier
Registration Dossier
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EC number: 268-018-3 | CAS number: 67989-88-2
Carcinogenicity
Administrative data
Description of key information
One chronic study is available with EDTA-CaNa2 in rats, and two supporting chronic studies are available with EDTA-Na3H in rats and mice, respectively (see also read across document in section 13).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Because no treatment-related tumours have been observed following chronic exposure to EDTA-CaNa2, and no treatment-related tumours have been observed following chronic exposure to EDTA-Na3H, and no such effects are expected for EDTA-Cu(NH4)2, this substance does not need classification for this endpoint.
Additional information
No treatment-related tumours were observed following chronic exposure to either EDTA-CaNa2 or EDTA-Na3H. In addition, other chelates did not demonstrate any pre-neoplastic or neoplastic lesions in repeated dose toxicity studies.
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