Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report, but no mortalities occured at the only concentration tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 8 days observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.GAUKLER, Offenbach, Germany
- Weight at study initiation: male animals 2.8 kg, female animals 3.0 kg
- Diet: ad libitum Ssniff K standard diet for rabbits and guinea pigs supplied by Intermast GmbH, Soest, Germany
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks, about 50 cm2
REMOVAL OF TEST SUBSTANCE
- Washing: after removal of coverage, washing with warm water or water/Lutrol
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 200 mg/kg bw - Duration of exposure:
- 24 h
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Signs of systemic toxicity: none Signs of local irritation: 24 hours after application parchment-like necrosis (after 8 days leather-like necrosis) and edema formation.
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
