Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report, but no mortalities occured at the only concentration tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 8 days observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.GAUKLER, Offenbach, Germany
- Weight at study initiation: male animals 2.8 kg, female animals 3.0 kg
- Diet: ad libitum Ssniff K standard diet for rabbits and guinea pigs supplied by Intermast GmbH, Soest, Germany
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks, about 50 cm2
REMOVAL OF TEST SUBSTANCE
- Washing: after removal of coverage, washing with warm water or water/Lutrol
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 200 mg/kg bw - Duration of exposure:
- 24 h
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Signs of systemic toxicity: none Signs of local irritation: 24 hours after application parchment-like necrosis (after 8 days leather-like necrosis) and edema formation.
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
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