Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
- Test material form:
- other: liquid
- Details on test material:
- Name of the test substance used in the study report: Methylpyrrolidin
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Test concentrations used were 1, 2 and 20% (v/v).
- Doses:
- 40, 100, 128, 160, 1280 mg/kg (original values 50, 100, 125, 160, 200, 1600 mm3/kg, values in mg/kg calculated using a density of 0.8003 g/mL)
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 88 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: ca. 0.11 mL/kg, value in mg/kg bw was calculated using the densitiy of 0.8003 g/mL (at 20 °C)
- Mortality:
- 40 mg/kg: no deaths; 80 mg/kg: 1/10 after 7 days; 100, 128, 160 and 1280 mg/kg: 10/10 after 7 days
- Clinical signs:
- dyspnea, spasms, abdominal and lateral position, cyanosis, apathy
- Body weight:
- no data
- Gross pathology:
- adherences and adhesions in the abdomen
Applicant's summary and conclusion
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