Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-04-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
Constituent 1
Test system
- Controls:
- other: not applicable
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): appr. 500 μL - Duration of treatment / exposure:
- not applicable
- Observation period:
- not applicable
- Number of animals:
- not applicable
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: breakthrough times in the Corrositex Assay [min.s]
- Value:
- 2.34
- Remarks on result:
- other:
- Remarks:
- Basis: other: mean of 7 vials. Time point: break through times. (migrated information)
In vivo
- Irritant / corrosive response data:
- Corrosive potential was determined on the basis of the average time recorded for the test substance to produce a change in the CDS.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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