1-methylpyrrolidine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

not specified

Principles of method if other than guideline:

according to BASF-internal standard

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-methylpyrrolidine

EC Number:

204-438-5

EC Name:

1-methylpyrrolidine

Cas Number:

120-94-5

Molecular formula:

C5H11N

IUPAC Name:

1-methylpyrrolidine

Test animals / tissue source

Species:

rabbit

Strain:

Vienna White

Test system

Vehicle:

unchanged (no vehicle)

Controls:

other: NaCl was applied to the other eye of the same animals

Amount / concentration applied:

0.05 mL

Duration of treatment / exposure:

1 h

Observation period (in vivo):

8 d

Number of animals or in vitro replicates:

2

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 1 h

Reversibility:

not reversible

Remarks on result:

other: corrosion was observed in treated eyes of both animals

Irritant / corrosive response data:

Already 1 hour after instillation of the test substance, greyish-brown corrosion of the conjunctiva, cornea and eyelids.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye)

Remarks:

Migrated information Criteria used for interpretation of results: EU