Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: NaCl was applied to the other eye of the same animals
- Amount / concentration applied:
- 0.05 mL
- Duration of treatment / exposure:
- 1 h
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosion was observed in treated eyes of both animals
- Irritant / corrosive response data:
- Already 1 hour after instillation of the test substance, greyish-brown corrosion of the conjunctiva, cornea and eyelids.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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