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Administrative data

Description of key information

In the IUCLID4 dataset on O,O-diethyl chlorothiophosphate, the results of several acute oral toxicity tests performed in rats are presented. The LD50 values are in the range of 953 - 1340 mg/kg bw/day.
Further information on the acute toxicity of O,O-diethyl chlorothiophosphate is provided in the IUCLID4 dataset of 2000. Acute inhalation toxicity studies revealed LC 50 values in the range of 0.154 – 0.615 mg/L after 4 hour exposure and of >2.137 mg/L after one hour exposure in rats. Acute dermal toxicity studies in rats resulted in LD50 values of 719 – 1439 mg/kg bw. Administration via intaperitoneal injection resulted in an LD50 of 170 mg/kg bw in mice.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
953 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
615 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
719 mg/kg bw

Additional information

In the IUCLID4 dataset on O,O-diethyl chlorothiophosphate, the results of several acute oral toxicity tests performed in rats are presented. The LD50 values are in the range of 953 - 1340 mg/kg bw/day.

Further information on the acute toxicity of O,O-diethyl chlorothiophosphate is provided in the IUCLID4 dataset of 2000. Acute inhalation toxicity studies revealed LC 50 values in the range of 0.154 – 0.615 mg/L (154 - 615 mg/m3) after 4 hour exposure and of >2.137 mg/L after one hour exposure in rats. Acute dermal toxicity studies in rats resulted in LD50 values of 719 – 1439 mg/kg bw. Administration via intaperitoneal injection resulted in an LD50 of 170 mg/kg bw in mice.

Justification for classification or non-classification

Based on the results of the acute toxicity studies and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP (1272/2008/EC), O,O-diethyl phosphorochloridothioate is classifed as toxic by inhalation and harmful if swallowed or by skin contact.