Registration Dossier

Administrative data

Description of key information

Skin irritation / corrosion:
The primary skin irritant effect of EP-2 was investigated according to OECD guideline 404. Possible skin irritating / corrosive effects were studied after 3 minutes and 1 hour exposure in 4 rabbits each.
The mean scores (24, 48 and 72 hours after application) after 3 minutes of exposure were 3.3 for erythema and 3.9 for oedema in all animals combined. After one hour of exposure, the mean scores (24, 48 and 72 hours) were3.3 for erythema and 4.0 for oedema for all animals combined. Furthermore, scar formation was observed in three of the rabbits exposed for one hour.
According to the Official Journal of the European Commumities, L 257, 1983, EP-2 shall be classified as skin irritating after 3 minutes of exposure and as corrosive after one hour of exposure.
In addition, in the IUCLID4 data set on O,O-diethyl phosphorocloridothioate, two skin irritation tests in rabbits are presented. The amount and concentration of the test substance applied is not stated. From Test 1 it is concluded that the substance is irritating after 3 minutes and corrosive after 1 hour of exposure. From Test 2 it is concluded that the substance is moderately irritating.
 
Eye irritation:
There is no eye irritation study available for O,O-diethyl chlorothiophosphate. According to column 2 of Annex VII of the REACH regulation, an eye irritation study does not need to be conducted for substances which are known to be corrosive to skin. As it is shown in Section 7.3.1 that EP-2 (O,O-diethyl chlorothiophosphate) is corrosive after one hour exposure to rabbit skin, no eye irritation study is, thus, necessary to be performed due to the known properties of the substance and due to animal welfare.
 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Additional information

Skin irritation / corrosion

The primary skin irritant effect of EP-2 was investigated according to OECD guideline 404. Possible skin irritating / corrosive effects were studied after 3 minutes and 1 hour exposure in 4 rabbits each. The mean scores (24, 48 and 72 hours after application) after 3 minutes of exposure were 3.3 for erythema and 3.9 for oedema in all animals combined. After one hour of exposure, the mean scores (24, 48 and 72 hours) were3.3 for erythema and 4.0 for oedema for all animals combined. Furthermore, scar formation was observed in three of the rabbits exposed for one hour. According to the Official Journal of the European Commumities, L 257, 1983, EP-2 shall be classified as skin irritating after 3 minutes of exposure and as corrosive after one hour of exposure.

In addition, in the IUCLID4 data set on O,O-diethyl phosphorocloridothioate, two skin irritation tests in rabbits are presented. The amount and concentration of the test substance applied is not stated. From Test 1 it is concluded that the substance is irritating after 3 minutes and corrosive after 1 hour of exposure. From Test 2 it is concluded that the substance is moderately irritating.  

Eye irritation

There is no eye irritation study available for O,O-diethyl chlorothiophosphate. According to column 2 of Annex VII of the REACH regulation, an eye irritation study does not need to be conducted for substances which are known to be corrosive to skin. As it is shown in Section 7.3.1 that EP-2 (O,O-diethyl chlorothiophosphate) is corrosive after one hour exposure to rabbit skin, no eye irritation study is, thus, necessary to be performed due to the known properties of the substance and due to animal welfare.  


Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

Based on the results of the skin irritation study and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP (1272/2008/EC), O,O-diethyl phosphorochloridothioate is classified as corrosive.