Registration Dossier
Registration Dossier
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EC number: 604-102-1 | CAS number: 13893-53-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards, is well documented and is accepted for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
- Reference Type:
- secondary source
- Title:
- Robust Summary for Aminoalkylnitrile Category
- Author:
- US EPA HPVIS
- Year:
- 2 006
- Bibliographic source:
- Doc ID 201-16274
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-amino-2,3-dimethylbutanenitrile
- Cas Number:
- 13893-53-3
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 2-amino-2,3-dimethylbutanenitrile
- Details on test material:
- Purity: >95%
brown liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Housing (at room temperature): 5 animals per cage.
Animals were fasted 18 hours before dosing.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Animals fasted for 18 hours
Doese with a 5% w/v corn oil disperion of the test substance - Doses:
- 31.3, 62.5, and 125 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- Animals were observed several times after dosing and twice daily over a 14-day period for physical condition and mortality.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 83 mg/kg bw
- 95% CL:
- 72 - 95
- Mortality:
- 31.3 mg/kg: No mortalities.
62.5 mg/kg: 1/10 animals died within 8 h after dosing.
125 mg/kg: 10/10 animals died within 8 h after dosing. - Clinical signs:
- other: 31.3 mg/kg: No toxic signs. 62.5 mg/kg: 1/10 animals showed tremors, tonic convulsion, salivation, and prostration. 125 mg/kg: 10/10 animals showed tremors, tonic convulsion, salivation, and prostration.
- Gross pathology:
- not performed
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
