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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Remarks:
Study was conducted as a part of determination of Critical Micelle Concentration. Well documented study and acceptable for assessment.
Qualifier:
according to guideline
Guideline:
other: OECD guidelines for the testing of chemicals no. 115 “Surface Tension of Aqueous Solution”
Version / remarks:
Adopted on 27th July 1995
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
other: ISO 304 “Surface active agents – Determination of surface tension by drawing up liquid films”
Version / remarks:
1985
Deviations:
not specified
Principles of method if other than guideline:
Study was conducted as a part of determination of Critical Micelle Concentration (CMC) and water solubility was derived in the study.
GLP compliance:
not specified
Type of method:
other: Determination of Critical Micelle Concentration (CMC)
Key result
Water solubility:
ca. 0.2 g/L
Temp.:
23 °C
pH:
ca. 7
Remarks on result:
other: Not completely water soluble
Details on results:
Not completely water soluble

The CMC was determined from the CMC curve by solving the two equations. The CMC for test substance determined to be 2.3 mg/L at pH 7.0. The operating temperature was room temperature, in this case 23°C. Also, the surface tension at 0.2 g/L solution has been determined to 28 mN/m. However, it should be noted that although the sample was not completely water soluble. Therefore, solid particles might have had an impact on the cmc value. Hence, it is important to realize that not all of the surfactant was present as monomers during the cmc determination.

Conclusions:
Under the study conditions, the water solubility as CMC for the test substance was determined to be 2.3 mg/L (Ulama & Anderson, 2010).
Executive summary:

A study was conducted to determine the water solubility as CMC of test substance, C12 -18 DAQ (99.6% active), according to the OECD guideline 115 and ISO 304 method using an automated tensiometer. The CMC was determined to be 2.3 mg/L at 23 °C. Also, the surface tension at 0.2 g/L was been determined to be 28 mN/m. However, it should be noted that although the sample was not completely water soluble and hence solid particles might have had an impact on the CMC value. The test substance was determined to be not completely water soluble. Under the study conditions, the water solubility as CMC for the test substance was determined to be 2.3 mg/L (Ulama & Anderson, 2010).

Description of key information

The water solubility of the test substance was determined using the critical micelle concentration (CMC) method, which is recommended for surface active substances (Ulama & Anderson, 2010).   

Key value for chemical safety assessment

Water solubility:
2.3 mg/L
at the temperature of:
23 °C

Additional information

(based on CMC)

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