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Short-term toxicity to fish

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Description of key information

LC50 (96 h): 42 mg/L for Oncorhynchus mykiss (nominal; OECD 203)

Key value for chemical safety assessment

Additional information

One experimental study investigating the short-term toxicity of ethylene diformate (CAS 629-15-2) to fish is available (Harris, 2013). The study was performed according to OECD 203 under GLP conditions using the rainbow trout Oncorhynchus mykiss. A range-finding study with three concentrations up to 100 mg/L resulted in complete mortality at 100 mg/L. Thus, the definite study was performed with five different concentrations up to 100 mg/L under semi-static conditions. The substance was found to hydrolyse in test medium with an approximate half-life of 11 h. The analytical measurement with gas chromatography (GC) revealed a decline in test concentration. Therefore, the possible effects of the parent substance and the hydrolysis products were tested in this study. After an exposure of 96 h, an LC50 of 42 mg/L and a NOEC of 32 mg/L resulted. Given that complete hydrolysis of the parent test item did not occur, and that toxicity cannot be attributed to the parent test item, the degradation product, or a mixture of the two, it was considered appropriate to calculate the results based on nominal parent test item concentrations only. Based on the result of this test, it is not expected that ethylene diformate and its hydrolysis products will exhibit acute toxic effects to freshwater fish.