Registration Dossier
Registration Dossier
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EC number: 236-948-9 | CAS number: 13560-89-9
Endpoint summary
Administrative data
Description of key information
Dechlorane Plus is practically insoluble in water with solubility
below 0.167 ng/L. No toxicity to fish (no mortality and no effect on
behaviour) was observed in one short-term toxicity study with 96 hours
exposure to up to 100 ppm nominal concentrations and two long-term
toxicity studies with exposure to nominal 0.1 ppm (analytical 0.069
-0.102 ppm) and nominal 1 ppm (analytical 0.001 - 0.046 ppm) for 30 days.
Studies with other aquatic species were not performed and not deemed
appropriate due to the very low water solubility and absence of any
toxicological effects reported in publications on environmental
monitoring in biota.
Liang et al. in a recent publication (2014) analysed different proteins
and showed that some protein concentrations in Chinese sturgeon were
altered upon exposure to 1, 10 and 100 mg/kg ww applied by single
intraperitoneal injection. 39 of 740 identified proteins were
significantly altered in concentration and 27 of those could be
identified. Their main functions were associated with oxidative stress,
cell proliferation (of Ca2+) and apoptosis, but no clinical signs of
toxicity were recorded.
Additional information
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