Registration Dossier
Registration Dossier
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EC number: 601-327-7 | CAS number: 114772-54-2
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 11 October 1996 to 28 November 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
- EC Number:
- 601-327-7
- Cas Number:
- 114772-54-2
- Molecular formula:
- C14H10BrN
- IUPAC Name:
- 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- SR 48941
Code: 3207
Chemical name: 4-bromomethyl-biphenyl-2-carbonitrile
CAS number: 114772-54-2
Batch: 6 R 00010
Appearence: Whrite to beige powder
Characteristics:
Solubility: practically insoluble in water (<0.01%)
Stability: stable under normal handling conditions
Melting point: 122.4°C
Organic carbon rate: 61.7%
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- 1.10^7 microorganisms/ml
30 ml of inoculum are intriduced in each flask. - Duration of test (contact time):
- 28 d
- Details on study design:
- Container: serie of glass flasks containing 3L of media.
Test: 2 referenced flasks FE1 and FE2 (SR48941 + inoculum)
Concentration of organic carbon: FE 1 : 10 mg/l (48.8 mg of SR48941) / FE2: 20 mg/l (98.0 mg of SR48941)
Control test: 2 flasks of FB1 and FB2 (inoculum control)
Inoculum control: 1 flask referenced Fc containing aniline (reference substance) at 20 mg/l in organic carbon (procedure control).
Inhibition control: (toxicity control): 1 flask referenced FI in order to verify an eventual inhibitor effect of the product SR48941, containing aniline at 20 mg/l in organic carbon and product at 20 mg/l of organic carbon (weight of SR48941: 98.5 mg).
Abiotic degradation control: 1 flask referenced FA containing the product at 20 mg/l of organic carbon and a sterilising agent (HgCl2) (weight of Sr48941: 99.5 mg).
System control: 1 abiotic control flask referenced FBA (media + HgCl2)
Temperature: 21 +/- 1°C (air-conditionned room, dark)
Aeration: compressed air purified in CO2 (30 to 50 ml/min)
Test duration: 28 days - acidification (HCL conc.) on 27th day
Reference substance
- Reference substance:
- aniline
- Remarks:
- 20 mg/l of organic carbon
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- biodegradation: 89% of theorical CO2
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the test conditions and the test period, the product SR 48941 is not readily biodegradable.
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