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Toxicity to microorganisms

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Description of key information

NOEC = 45.5 mg/L (from ready biodegradation test, 78.7% biodegradation in toxicity control within 14 days)

Key value for chemical safety assessment

Additional information

No standard studies evaluating the effect of Glycerides, mixed C8-10 and succinyl (CAS No. 91744-56-8) on respiration inhibition of aquatic microorganisms are available. Therefore, a ready biodegradability study is used to derive a NOEC for this endpoint. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment, Chapter R.7b (ECHA 2012).

A substance can be assumed to be not inhibitory of the activity of aquatic microorganisms if, in the toxicity control of a ready biodegradation test, more than 25% biodegradation occurs within a period of 14 days (OECD Guideline 301). For Glycerides, mixed C8-10 and succinyl, a biodegradation screening test according to OECD 301B is available (Flach, 2012). This test includes a toxicity control containing 45.5 mg/L of test material. Within 14 days, 78.7% biodegradation took place in this toxicity control clearly indicating the lack of toxic potential of Glycerides, mixed C8-10 and succinyl to activated sludge microorganisms, and therefore, the test item concentration of 45.5 mg/L can be used as a NOEC value.

Based on the above information it is considered that Glycerides, mixed C8-10 and succinyl is not inhibitory of microorganisms’ activity and further testing for this endpoint is not deemed necessary.