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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given. Lack of details on the test material and limited documentation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
lack of details on the test material and limited documentation
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Glycerides, mixed C8-10 and succinyl
EC Number:
294-620-0
EC Name:
Glycerides, mixed C8-10 and succinyl
Cas Number:
91744-56-8
Molecular formula:
Not applicable: Complex UVCB substance
IUPAC Name:
Glycerides, mixed C8-10 and succinyl
Details on test material:
- Name of test material (as cited in study report): only trade name given
- Physical state: clear oil-like material
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Bantin & Kingman Ltd., Hull, UK
- Weight at study initiation: 150 ± 20 g
- Fasting period before study: food was withheld for 18 h prior to test substance administration.
- Housing: animals were housed in groups of 5 rats of the same sex in grid-floor cages.
- Diet: standard laboratory rodent diet (41B pellets) (Dixon & Sons. (Ware) Ltd., Ware, UK), ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5 mL/kg bw
No. of animals per sex per dose:
5
Control animals:
other: not required
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: animals were observed immediately after administration and daily thereafter. Any deaths or signs of toxicity were recorded. Body weights were determined on Day 0 (study initiation), Day 3 and Day 14 (study termination).
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, mortality, body weights

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 045 mg/kg bw
Based on:
test mat.
Remarks on result:
other: corresponding to 5 mL/kg bw based on a density of 1.009 g/cm³
Mortality:
No mortality occurred during the study period.
Clinical signs:
No clinical signs of toxicity were observed up to the end of the 14-day observation period.
Body weight:
No effect on body weight was noted during the whole study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: not classified
DSD: not classified