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Physical & Chemical properties

Dissociation constant

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Administrative data

Endpoint:
dissociation constant
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Value from a peer-reviewed handbook, acceptable for assessment.

Data source

Reference
Reference Type:
review article or handbook
Title:
Ionization Constants of Organic Acids in Aqueous Solution
Author:
Serjeant, E. P., and Dempsey, B.,
Year:
1979
Bibliographic source:
Pergamon, Oxford, UK

Materials and methods

Principles of method if other than guideline:
Not specified in the handbook.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Citric acid
EC Number:
201-069-1
EC Name:
Citric acid
Cas Number:
77-92-9
Molecular formula:
C6H8O7
IUPAC Name:
citric acid

Results and discussion

Dissociating properties:
yes
Dissociation constantopen allclose all
No.:
#1
pKa:
3.14
Temp.:
20 °C
No.:
#2
pKa:
4.77
Temp.:
20 °C
No.:
#3
pKa:
6.39
Temp.:
20 °C

Applicant's summary and conclusion