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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

The 21-d NOEC for monoethanolamine in Daphnia magna is 0.85 mg/L, after correction for molecular weight an effect concentration of 5.22 mg/L for tris[(2-hydroxyethyl)ammonium] citrate will be used in the assessment.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
5.22 mg/L

Additional information

No long-term studies with invertebrates are available for tris[(2-hydroxyethyl)ammonium] citrate. Tris[(2-hydroxyethyl)ammonium] citrate is the neutral salt of monoethanolamine and citric acid. Monoethanolamine and citric acid are the starting materials for the synthesis of tris[(2-hydroxyethyl)ammonium] citrate, and the only difference is that in tris[(2-hydroxyethyl)ammonium] citrate the substances are present in their ionic forms as a monoethanolamine cation and a citrate anion. It is expected that the ecotoxicological properties of tris[(2-hydroxyethyl)ammonium] citrate shall be governed by the properties of monoethanolamine and citric acid (for more details see reporting format for the analogue approach in Appendix A.2).

A GLP-compliant OECD 211 test with Daphnia magna is available for monoethanolamine (NITE, 1996a). The 21-d NOEC is 0.85 mg/L, a safety factor need not to be applied to this value. Instead, the effect concentration will be corrected for molecular weight.The effect concentration for tris[(2-hydroxyethyl)ammonium] citrate is 5.22 mg/L.

No study is available for citric acid.

The effect concentration of 5.22 mg/L will be used in the assessment.