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Studies with terrestrial organisms are not available. Tris[(2-hydroxyethyl)ammonium] citrate is the acidic salt of monoethanolamine and citric acid. Monoethanolamine and citric acid are the starting materials for the synthesis of tris[(2-hydroxyethyl)ammonium] citrate, and the only difference is that in tris[(2-hydroxyethyl)ammonium] citrate the substances are present in their ionic forms as a (2-hydroxyethyl)ammonium cation and partially deprotonated dihydrogen citrate anion. It is expected that the ecotoxicological properties of tris[(2-hydroxyethyl)ammonium] citrate shall be governed by the properties of monoethanolamine and citric acid (for more details see reporting format for the analogue approach in Appendix A.2).

Because the log Kow values for monoethanolamine and citric acid are low (-1.31 and -1.55, respecectively), it is expected that tris[(2-hydroxyethyl)ammonium] citrate will mainly partition to the water compartment. Therefore, direct and indirect exposure of the terrestrial compartments is not expected.