Registration Dossier
Registration Dossier
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EC number: 203-842-9 | CAS number: 111-18-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Acutely toxic for aquatic invertebrates
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.94 mg/L
Additional information
To determine the short-term toxicity of N,N,N',N'-Tetramethylhexamethylenediamine (TMHDA; CAS 111 -18 -2) to aquatic invertebrates, a 48-hr acute Daphnia magna toxicity study was conducted according to EPA guideline 797.1300. Nominal test concentrations ranged from 0.313 mg/L to 20.0 mg/L. The test system was semi-static, as test solutions were renewed after 24 hours. Adjustment of pH was not specfied, but pH ranged between 7.6 and 7.9. The number of immobile animals in each test vessel as well as any abnormal behaviour were recorded at 0, 24 , and 48 hours. The 48 -hour EC50 was estimated to be 6.94 mg/L based on measured concentrations (Danish EPA 2000; report no. 81089/270).
In conclusion, TMHDA is considered to be acutely toxic for aquatic invertebrates.
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