Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-842-9 | CAS number: 111-18-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 21-day EC10 for daphnia reproduction was found to be 0.86 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.86 mg/L
Additional information
The long-term toxicity of N,N,N',N'-Tetramethylhexamethylenediamine (CAS 111 -18 -2) was assessed in an OECD 211 reproduction test (under GLP) using Daphnia magnaas test organism (BASF SE 2013, report no. 51E0487/11E119). Daphnia were exposed to the test substance at nominal concentrations ranging from 0.10 to 4.6 mg/L. Parent mortality, abnormal effects and numbers of live and dead offspring were assessed every day. Test concentration analyses was carried out by HPLC.
The 21 -day NOEC for reproduction was found to be 1.0 mg/L and the EC10 was 0.86 mg/L. The 21 -day NOEC for mortality was 2.2 mg/L and the EC10 3.03 mg/L. The results are based on analytically verified time-weighted average concentrations, the pH in the test solutions was not adjusted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
