Hexahydro-4,7-methano-1H-indenyl acrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: study report which meets basic scientific principles, acceptable with restrictions (limited documentation)

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Reference 3

Reference Type:

other company data

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

(adopted 1981)

Deviations:

yes

Remarks:

no analytical verification of the test atmosphere concentrations

Principles of method if other than guideline:

The inhalation hazard test was conducted according to the method described by Smyth et al. (1962).
Smyth HF et al. (1962). Am. Ind. Hyg. Ass. J. 23: 95-107.

GLP compliance:

no

Test type:

other: Inhalation Hazard Test

Test material

Test material information

Constituent 1

Reference substance name:

Hexahydro-4,7-methano-1H-indenyl acrylate

EC Number:

235-697-2

EC Name:

Hexahydro-4,7-methano-1H-indenyl acrylate

Cas Number:

12542-30-2

Molecular formula:

C13 H16 O2

IUPAC Name:

2-Propenoic acid hexahydro-4,7-methano-1H-indenyl ester

Details on test material:

- Name of the test substance used in the study report: Dihydrodicyclopentadienylacrylat (abbreviation: DCPA)
- Analytical purity: 99%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Mean body weight of animals:
- males: 253 g (test group 1); 259 g (test group 2);
- females: 188 g (test group 1); 180 g (test group 2).

- Diet (ad libitum): HERITAN MRH-Haltung, complete diet for mice, rats, and hamsters, Heinrich Eggersmann, Rinteln.
- Water (ad libitum): tap water

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Inhalation of an atmosphere enriched with vapour at 20°C. For enrichment, 200 L air/h was conducted through a Iayer of about 5 cm of the product.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

Mean concentration: approx. 1 mg/L

No. of animals per sex per dose:

6 animals/sex/dose (two groups)

Control animals:

yes

Statistics:

none

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

>= 1 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

7 h

Remarks on result:

other: IHT: No mortality was observed when 12 rats were exposed for 7 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound.

Mortality:

No mortality occurred.

Clinical signs:

other: No clinical signs were observed.

Body weight:

Body weight
- males: 317 g (test group 1), 333 g (test group 2);
- females: 290 g (test group 1), 201 g (test group 2)

Gross pathology:

Nothing abnormal detected.

Any other information on results incl. tables

The test substance concentration was estimated to be approx. 1 mg/L at 20 °C. Vapour saturation was calculated to be approx. 0.11 mg/L at 20 °C. Concentrations above the vapour saturation treshold should carefully be considered to be aerosols. Thus, the animals were exposed to a saturated vapour atmosphere, possibly in the presence of some aerosol particles.