Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methological deficiencies (Substance weight increase instead of decrease during IRT, probably due to hygroscopic properties of test substance. Therefore one can not be sure whether the animals were exposed to any test substance at all.)

Data source

Reference Type:
study report
Report date:

Materials and methods

GLP compliance:
Test type:
other: Inhalation Risk Test (IRT)
Limit test:

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate
EC Number:
EC Name:
Tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate
Cas Number:
Molecular formula:
tris{2-[2-(2-methoxyethoxy)ethoxy]ethyl} borate
Constituent 2
Reference substance name:
B-TEGME, the major component of B-TTEGME
B-TEGME, the major component of B-TTEGME
Details on test material:
- Name of test material (as cited in study report): Methyltriglykol-o-borate
- Substance type: Borated Glycol Ether
- Physical state: Clear colourless liquid
- Analytical purity: Confidential details on test material
- Impurities (identity and concentrations): Not provided
- Composition of test material, percentage of components: Confidential details on test material
- Purity test date: Not provided
- Lot/batch No.: 4200 (SNC Sample No.); Indent 9450/9486
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided

Test animals

Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
other: no data
Details on inhalation exposure:
"Inhalation einer mit Dampf bei C gesättigten Atmosphäre: 20 °C. Zur Sättigung wurde durch eine ca. 5 cm hohe Schicht des Produktes Luft geleitet" (Inhalation of a vapour saturated atmosphere at 20 °C. In order to obtain saturation of the atmosphere, air was passed through a 5 cm column of the product.)
Analytical verification of test atmosphere concentrations:
Details on study design:
Expositionszeit: 3min, 10min, 30 min, 1 h, 3 h 8 h.
Further details were not provided.

Results and discussion

No mortalities within 8 h exposure period and 7 day observation period.
Clinical signs:
other: No effects on clinical signs.
Body weight:
No effects on body weight.
Gross pathology:
No effects on gross pathology.

Any other information on results incl. tables

The test was repeated with additional 3 animal/sex, no mortalities or other effects could be observed. Again there was a test substance weight gain instead of loss (+ 1 g). The substance weight gain might be due to hygroscopic properties of the TS.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information
No data
Executive summary:

B-TEGME is considered to have a similar toxicological profile as B-TTEGME.

A nominal concentration could not be calculated because the substance gained weight instead of lost weight during the test.