2,5-dihydrofuran

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting (no information on duration of treatment) but otherwise adequate for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1961

Report date:

1961

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Rabbits were exposed to the test substance by oral gavage.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,5-dihydrofuran

EC Number:

216-957-4

EC Name:

2,5-dihydrofuran

Cas Number:

1708-29-8

Molecular formula:

C4H6O

IUPAC Name:

2,5-dihydrofuran

Details on test material:

- Name of test material (as cited in study report): 2,5-Dihydrofuran
- Purity: 94%
- Physical state: colorless clear liquid

Test animals

Species:

rabbit

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.5 - 2.9 and 2.7 - 2.9 kg, for females and males respectively

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

- 2 animals dosed 0.4 mL/kg; 2 times per week
- 2 animals dosed 0.4 mL/kg; first week ones, thereafter 2 times per week
- 1 animal dosed 0.4 mL/kg; first week ones, thereafter 3 times per week treated with 0.2 mL/kg
- 1 animal dosed 0.4 mL/kg; first week ones, thereafter 4 times per week treated with 0.2 mL/kg

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

- not specified

Control animals:

no

Examinations

Observations and examinations performed and frequency:

Clinical observations

Sacrifice and pathology:

GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes

Results and discussion

Results of examinations

Details on results:

CLINICAL SIGNS AND MORTALITY: Diarrhea was observed in all exposed animals. All exposed animals died.
PATHOLOGY: Autopsy revealed in 4 out of 6 animals a mild to moderate edema in the lungs. No effects on liver, kidneys and hematological parameters were observed. In one exposed animal kidney damage was histologically detectable.

Effect levels

Dose descriptor:

NOAEL

Basis for effect level:

other: No NOAEL derivation was possible

Remarks on result:

not determinable

Remarks:

no NOAEL identified

Target system / organ toxicity

Critical effects observed:

not specified