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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Description of key information

The dissociation constant of the amine group is 10.47 at 0.01 M and 25 °C according to a GLP study. We can consider that this value is approximately the same at 20 °C.

Key value for chemical safety assessment

pKa at 20°C:

Additional information

We determined experimentally the pKa of the amine group in the molecule; the other ionizable group in this molecule is the alcohol group but we did not try to determine its dissociation constant experimentally since it was considered to be outside of the environmentally relevant pH range (and also outside the practical experimental range). Therefore, the dissociation constant of this group was calculated using specialist estimation software; using I-Lab 2.0, ACD/Labs, the dissociation constant of the alcohol group was estimated to be 15.86 +/- 0.10.