Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-254-5 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Similar to OECD guideline. No GLP study. Analytical monitoring was not conducted.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- not specified
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- Stock solution was prepared with DMSO:HCO-40 =9:1 (32-320 mg/l).
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Nominal and measured concentrations:
- 5 nominal concentrations (0.32-3.2 mg/l).
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Remarks on result:
- other: 95% confidence limits: 3.2-4.4 mg/l
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Remarks on result:
- other: 95% confidence limits: 2.3-2.7 mg/l
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 0.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% confidence limits:0.59-0.60 mg/l
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: p < 0.05
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 21-day NOEC for reproduction is 0.32 mg/l.
- Executive summary:
Long-term toxicity of 6-tert-butyl-2,4-xylenol was studied in Daphnia, using a method similar to OECD guideline 211 for 21 days.
The 21-day NOEC for reproduction is 0.32 mg/l.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Rationale for reliability incl. deficiencies:
- other:
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.32 mg/L
- Remarks on result:
- other: read-across from an analogue for which NOEC (21 d) = 0.32 mg/L
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 21-day NOEC for reproduction of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 0.32 mg/L.
- Executive summary:
The 21-day NOEC for reproduction of 6-tert-butyl-2,4-xylenol is 0.32 mg/L (Results of Eco-toxicity tests of chemicals conducted by Environment Agency in Japan). Based on this result, the read-across approach was applied and the 21-day NOEC for reproduction of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 0.32 mg/L.
Referenceopen allclose all
Description of key information
Key study: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.
21 -day NOEC for reproduction = 0.32 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.32 mg/L
Additional information
Key study: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.
21 -day NOEC for reproduction = 0.32 mg/l
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
Based on published experimental data on the analogue 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the read-across approach is applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
