Copper chloride

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable study report wich meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Principles of method if other than guideline:

BASF test:
Suspensions of the test substance in 0.5% Carboxylmethyl cellulose (CMC) aqueous preparation were injected into the peritoneal cavity of the mice. Group-wise documentation of clinical signs was performed over the 14-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Copper chloride

EC Number:

231-842-9

EC Name:

Copper chloride

Cas Number:

7758-89-6

Molecular formula:

Cl Cu

IUPAC Name:

λ¹-copper(1+) chloride

Details on test material:

- Name of test material (as cited in study report): Kupfer-I-Chlorid
- Analytical purity: 98 - 99%

Test animals

Species:

mouse

Strain:

NMRI

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males 27 g, females 26 g (mean)

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: 0.147 - 0.464% suspension in 0.5% aqueous CMC preparation

Doses:

14.7, 21.5, 31.6 and 46.4 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Statistics:

Probit analysis

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 17 mg/kg bw

Mortality:

LD50 = approx. 17 mg/kg bw.

Clinical signs:

Irregular respiration, dyspnoea, apathy and poor general state were observed within 30 min after test substance injection.

Body weight:

Body weight gain was generally observed in the course of the study.

Gross pathology:

At necropsy, no intraabdominal substance precipates and adhesions were observed in animals that died during the course of the study. Adipose tissus showed in small number of animals necrotic changes.
In sacrificed animals some tissue adhesions were observed.

Any other information on results incl. tables

Dose (mg/kg bw)	Mortality Dead/Treated
	1 hour		24 hours		48 hours		7 days		14days
	male	female	male	female	male	female	male	female	male	female
14.7	0/5	0/5	0/5	0/5	0/5	0/5	0/5	1/5	0/5	1/5
21.5	0/5	0/5	2/5	0/5	3/5	0/5	5/5	1/5	5/5	1/5
31.6	0/5	0/5	3/5	2/5	3/5	2/5	5/5	3/5	5/5	3/5
46.4	0/5	0/5	1/5	0/5	1/5	1/5	2/5	2/5	2/5	2/5