Registration Dossier
Registration Dossier
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EC number: 246-644-8 | CAS number: 25134-21-8
Endpoint summary
Administrative data
Description of key information
Additional information
Acute immobilisation to Daphnia magna, algal growth inhibition to unicellular freshwater green alga and acute toxicity to fish have been investigated.
In Daphnia no effects were observed at a concentration of 100 mg/L. In fish the LC50 was estimated to be 359 mg/L. In algae, the substance was found to inhibit growth after 72 hours exposure. The EC50 values for inhibition of specific growth rate (ErC50) and yield (EyC50) were >100mg/L. EC10 values for inhibition of specific growth rate (ErC50) was 92.6 mg/L and yield (EyC50) was 74.7mg/L.NOEC was determined to be 66.7 mg/L. The test substance rapidly hydrolyses in water yielding the di-acid degradation product that significantly affected pH. A limit test conducted at a concentration of 100 mg/L and with adjustment of pH had no significant effects on growth of the algae. In accordance with ECHA guidance oninformation requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, the ErC50 endpoint was used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
Toxicity to microorganisms has been investigated in an activated sludge respiration inhibition test according to OECD test methods. The substance caused a concentration related inhibition ranging from 11% at 46.7 mg/L to 98% at 2000 mg/L. The EC50 was 311.82 mg/L while the EC10 was 59.1 mg/L. A concentration of 13.3 mg/L caused no significantly different effects relative to untreated controls and was regarded as the NOEC.
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