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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
No toxicokinetic studies are available on diethyl sulphide. However, studies are available for the structural analogue dimethyl sulphide

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Two supporting studies were identified for dimethyl sulphide, a structural analogue of diethyl sulphide.

Following single acute exposure of mice to atmospheres of dimethyl sulphide vapors from 6.8% to 50.6% (w/v), dimethyl sulphide was distributed in all tissues almost equally, except for the lungs where the concentration was much lower. In addition, JECFA stated that simple alkyl sulphides (including dimethyl sulphide) are oxidised (by enzymes from the cytochrome P450 superfamily and flavin-containing monooxygenases) to sulfoxides, and subsequently to sulfones in mammals. These are the major urinary metabolites of simple alkyl sulphides (Terazawa et al., 1991).


The subcutaneous injection of dimethyl sulphide to a rabbit leads to the excretion of dimethyl sulfoxide and dimethyl sulfone in the urine and to the expiration of a malodorous material (presumably dimethyl sulphide) (Williams et al., 1966).