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EC number: 206-526-9 | CAS number: 352-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1993-11-15 to 1994-04-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to a OECD guideline and follows GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limit test at 5000 mg/kg bw
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl ethyl sulphide (CAS # 624-89-5)
- IUPAC Name:
- Methyl ethyl sulphide (CAS # 624-89-5)
- Details on test material:
- - Name of test material (as cited in study report): methyl ethyl sulfide
- Molecular formula (if other than submission substance): C3H8S
- Molecular weight (if other than submission substance): 76.16 g
- Smiles notation (if other than submission substance): C(SC)C
- InChl (if other than submission substance): InChI=1/C3H8S/c1-3-4-2/h3H2,1-2H3
- Substance type: pure active substance
- Physical state: clear colorless liquid
- Stability under test conditions: data not available
- Storage condition of test material: room temperature, protected from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc., Portage, Michigan
- Age at study initiation: young adults
- Weight at study initiation: from 248 to 288 g for males and from 253 to 264 g for females (on day -1)
- Fasting period before study: yes (overnight)
- Housing: individually in stainless steel cages
- Diet: Purina certified Rodent chow #5002 ad libitum
- Water (e.g. ad libitum): municipal tap water treated by reverse osmosis or deionization, ad libitum
- Acclimation period: for a minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 62 to 72 °F (# 16.7 to 22.2°C)
- Humidity: 40 to 58%
- Air changes: 10 to 12 air changes per hour
- Photoperiod: 12 hrs dark / 12 rs light
IN-LIFE DATES: From 15-DEC-1993 to 29-DEC-1993
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 6 mL/kg
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> clinical signs: 2 times on study day 0, and daily thereafter
> body weight: prior to fasting (day -1), prior to dosing on day 0, for all surviving animals on day 7 and 14, or at the time for death
- Necropsy of survivors performed: yes - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- One male rat died on day 1. All other animals survived up to the end of the study
- Clinical signs:
- other: The most notable clinical abnormalities observed during the study included salivation which was noted in 8/10 animals on study day 0 only, piloerection noted in 8/10 animals during the study day 0 to 2 interval, wobbly gait noted in all test animals on st
- Gross pathology:
- Gross internal findings noted at necropsy for the animal that died included clear yellow-red fluid contents in the urinary bladder, light green staining of glandular mucosa in the stomach and greenish-red mucoid contents in the entire tract of the small intestine. No gross internal findings were observed at necropsy on study day 14 for the surviving animals.
Any other information on results incl. tables
Table 1: Number of animals dead and with evident toxicity and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (day) |
Number with evident toxicity (#/total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
5000 |
1/5 |
0/5 |
1/10 |
Day 1 |
5/5 |
5/5 |
10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of Methyl Ethyl Sulphide was estimated to be greater than 5000 mg/kg in the rat.
- Executive summary:
In an acute oral toxicity study (similar to OECD testing guideline 401 and according to GLP), groups of fasted, young adults Sprague-Dawley rats (5/sex) were given a single oral dose of undiluted methyl ethyl sulphide by gavage at dose of 5000 mg/kg bw (limit test) and observed for 14 days.
One male rat died on day 1. All other animals survived up to the end of the study. Clinical signs were observed in all animals: salivation, piloerection, wobbly gait, decreased activity, lacrimation, eyelids partially closed, transient incidences of urine stain, transient incidences of rales, rough haircoat, decreased/no defecation, dark material around the facial area, low food consumption. Gross internal findings noted at necropsy for the animal that died included clear yellow-red fluid contents in the urinary bladder, light green staining of glandular mucosa in the stomach and greenish-red mucoid contents in the entire tract of the small intestine. No gross internal findings were observed at necropsy on study day 14 for the surviving animals. The oral LD50 (combined males/females) was > 5000 mg/kg bw.
This study received a Klimisch score of 1 and is classified as reliable with restriction because the study was performed according to OECD guidelines and followed GLP.
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