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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Piperazine (CAS No 110-85-0) is the parent molecule from which piperazine, compound with phosphoric acid or piperazine phosphate (CAS No 1951-97-9) is synthesized. In medicine piperazine is used in the form of the hexahydrate or as the citrate, tartrate, phosphate (1951-97-9) or adipate. Thus, piperazine and piperazine phosphate can be considered as belonging to the same category.

Data source

Reference
Reference Type:
publication
Title:
BASF, Gewerbehygiene und Toxikologie, 1980
Author:
BASF
Year:
1980
Bibliographic source:
Gewerbehygiene und Toxikologie, 1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard method for inhalation toxicity
GLP compliance:
no
Test type:
other: 14 day study (test comp

Test material

Constituent 1
Reference substance name:
Piperazine
EC Number:
203-808-3
EC Name:
Piperazine
Cas Number:
110-85-0
IUPAC Name:
piperazine

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Piperazine chips were filled in a glass flask, and placed in a water bath at 20oC. Air was flown through the chips at a rate of 200 l per hour. The air stream, wit dust particles and volatile piperazine, was passed through glass chambers with rats, in total 12 animals. The exposure time was 3, 10, 30 minutes, 1, 3 or 7 hours. The animals were observed for 14 days after the test.
Duration of exposure:
> 2 - < 420 min
Concentrations:
Details not available
No. of animals per sex per dose:
Total number of animlas - 12
Control animals:
not specified
Details on study design:
Piperazine chips were filled in a glass flask, and placed in a water bath at 20oC. Air was flown through the chips at a rate of 200 l per hour. The air stream, with dust particles and volatile piperazine, was passed through glass chambers with rats, in total 12 animals. The exposure time was 3, 10, 30 minutes, 1, 3 or 7 hours. The animals were observed for 14 days after the test.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
other: death and other respiratory irritation symptoms
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: No animals died and no symptoms were found at autopsy.
Mortality:
There was no mortality during the entire duration of test
Clinical signs:
other: No clinical symptoms observed at autopsy

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The chemical piperazine was not found to be acutely toxic by the inhalation route in the 7 hours study conducted with Rats
Executive summary:

The chemical piperazine was not found to be acutely toxic by the inhalation route in the 7 hours study conducted with Rats