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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(p-isocyanatophenyl) thiophosphate
EC Number:
223-981-9
EC Name:
Tris(p-isocyanatophenyl) thiophosphate
Cas Number:
4151-51-3
Molecular formula:
C21H12N3O6PS
IUPAC Name:
O,O,O-tris-(4-isocyanatophenyl) thiophosphate

Test animals / tissue source

Species:
rabbit
Strain:
Himalayan
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Sex: female
- Source: LPT Laboratory of Pharmacology and Toxicology KG, Löhndorf, Germany
- Age at study initiation: appr. 3.5 months
- sex: males

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: one untreated eye of test animals served as control
Amount / concentration applied:
Amount: 0.1 ml

Duration of treatment / exposure:
single treatment; the lid was held together for about one second after instillation
Observation period (in vivo):
the eyes were examined ophthalmoscopically with a slit lamp prior to the administration and also 1, 24, 48, 72 hours post application. 24 hours after administration the eyes were treated additionally with fluorescein and examined.
Number of animals or in vitro replicates:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing: none

SCORING SYSTEM: Draize

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks:
cornea, iris, and conjunctivae
Basis:
mean
Time point:
other: 24 h, 48 h, 72 h
Score:
0
Max. score:
4
Remarks on result:
other: 1 hour after instillation redness of conjunctivae (grade 1; all animals), chemosis (grade 1; 1 animal) , and cornea opacity (grade 1; 2 animals) was observed
Other effects:
There were no systemic intolerance reactions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:



Classification: not irritating
Executive summary:

In a study performed according to OECD 405 the test item (27% tris(p-isocyanatophenyl)thiophosphate in ethyl acetate)

did not induce irritant effects in the eye of rabbits. There were no systemic intolerance reactions.