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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study report that meets generally accepted scientific principles.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium chloride
EC Number:
233-140-8
EC Name:
Calcium chloride
Cas Number:
10043-52-4
Molecular formula:
CaCl2
IUPAC Name:
calcium dichloride

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
24 hours
Doses:
5000 mg/kg
No. of animals per sex per dose:
2

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality
Clinical signs:
other: no adverse effects

Any other information on results incl. tables

The dermal LD50 was >5000 mg/kg.  All four rabbits topically 
treated with  the test material survived.  No adverse effects 
were observed following  treatment.  Topical responses observed 
on the application sites of test  rabbits 24 hours post-treatment 
included slight (1/4) or moderate (3/4)  redness, moderate (3/4) 
or marked (1/4) swelling and moderate (2/4) or marked (2/4) necrosis. 
Gross necropsy examination of rabbits 2 weeks post-treatment revealed 
skin lesions at or near the site of administration, characterized 
by scab formation, skin thickening and subchronic inflammation. 
Internal observations were not considered to be the result of compound 
exposure  and/or absorption.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on this study the LD50 for dermal route in rabbits is higher than 5000 mg/kg.bw. Therefore according to EU and UN GHS criteria no classification is required for dermal acute toxicity.
Executive summary:

In this study males and females New Zealand rabbits were exposed dermally during 24 hours to 5000 mg/kg.bw of undiluted calcium chloride. No mortality occurred. Calcium chloride has a very low dermal acute toxicity and no classification is required according to EU and UN GHS criteria.