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EC number: 293-262-2 | CAS number: 91053-00-8 A complex combination of hydrocarbons obtained from distillation of the butadiene-free C4 fraction of a naphtha steam-cracking process. It consists predominantly of olefinic hydrocarbons having carbon numbers of C8, C12, C16 and C20 and boiling in the range of approximately 95°C to 120°C (203°F to 248°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study. Deviation: 6 animals (3 males and 3 females) were used
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- (6 animals (3 males and 3 females) were used)
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- Dodecene, branched
- EC Number:
- 306-479-5
- EC Name:
- Dodecene, branched
- Cas Number:
- 97280-83-6
- IUPAC Name:
- Dodecene, branched
- Details on test material:
- - Name of test material (as cited in study report): isododecene
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr K Thomae GmbH, 7950 Biberach, Germany
- Age at study initiation: approximately 8-9 weeks
- Weight at study initiation: mean weight 283 g (males), 192 g (females)
- Housing: in groups of 3/sex in type D III wire mesh cages (without bedding)
- Diet: KLIBA 24-343-4 rat/mouse laboratory diet ad libitum except during exposure
- Water: ad libitum except during exposure
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24°C
- Humidity: 30-70%
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus/atmosphere generation: the product was introduced to a height of 5 cm into a glass bottle (generator) with a sintered glass disk (pore-size 90-150 pm, diameter 30 mm) and the weight was determined. The generator containing the product was placed in a waterbath maintained at 20°C, and a stream of 200 L/hr compressed air was supplied to a downstream mixing chamber.
- Method of holding animals in test chamber: the air and test substance was passed through a glass distributor to 6 glass tubes in which the animals were held.
- After 30 minutes, the generator was replaced by a new one containing fresh test substance as described above. This generator was used for the remainder of the test.
- Temperature in air chamber: between 19-25°C - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- the amount of test substance used was determined by reweighing the generators. The nominal concentration was calculated from the amount of test substance consumed and the air volume.
- Duration of exposure:
- 7 h
- Concentrations:
- 3.8 mg/L (calculated)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily check for mortality; clinical examinations were made each workday
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3.8 mg/L air (nominal)
- Exp. duration:
- 7 h
- Remarks on result:
- other: vapour
- Mortality:
- None
- Clinical signs:
- other: other:
- Gross pathology:
- No abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of isododecene was greater than 3.8 mg/L.
- Executive summary:
There was no mortality following head/nose-only 7 hr exposure to 3.8 mg isododecene/L (calculated) to 3 rats/sex.
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