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EC number: 293-262-2 | CAS number: 91053-00-8 A complex combination of hydrocarbons obtained from distillation of the butadiene-free C4 fraction of a naphtha steam-cracking process. It consists predominantly of olefinic hydrocarbons having carbon numbers of C8, C12, C16 and C20 and boiling in the range of approximately 95°C to 120°C (203°F to 248°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-03-17 to 1994-07-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restrictions because it was conducted according to OECD 422 guidelines and was GLP complaint.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Tetradec-1-ene
- EC Number:
- 214-306-9
- EC Name:
- Tetradec-1-ene
- Cas Number:
- 1120-36-1
- Molecular formula:
- C14H28
- IUPAC Name:
- tetradec-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Blended from equal amounts of Neodene 14 alpha olefin, alpha olefin C14 1-tetradecene, and 1-tetradecene Gulftene 14
- Substance type: C14 alpha olefin
- Physical state: Clear colourless liquid
- Analytical purity: 99.0% to 99.98%
- Lot/batch No.: Neodene 14 alpha olefin 20202-45-1050, alpha olefin C14 1-tetradecene 300-954, and 1-tetradecene Gulftene 14 CBN0048
- Expiration date of the lot/batch: Only provided for Neodene 14 alpha olefin, 1994-12
- Storage condition of test material: Room temperature under nitrogen
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc., Portage, Michigan
- Age at study initiation: (P) Males: 6 weeks; Females: 8 weeks; F1 offspring not treated
- Weight at study initiation: (P) Males: 159 to 220 grams; Females: 184 to 242 grams
- Fasting period before study: No
- Housing: Individually except during cohabitation; males were also housed 2 to 3 to a cage during the first 4 days of acclimation
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 11 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 to 25°C
- Humidity (%): 21 to 79%
- Air changes (per hr): 10 to 12
- Photoperiod (hrs dark / hrs light): 12 hours dark/12 hours light
IN-LIFE DATES: From:1994-03-17 To:1994-05-03
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: After stirring the blended test material for 15 minutes, a specified amount of test material was added to a flask with half of the corn oil. The flasks were capped and inverted several times, then the remaining corn oil was added and the procedure repeated. The solution was then stirred for 15 minutes. Preparations were kept for a maximum of 28 days.
VEHICLE
- Concentration in vehicle: 0, 20, 100, or 200 mg/mL
- Amount of vehicle (if gavage): 5 mL/kg
- Lot/batch no. (if required): APR0695A, OCT0494A, and DEC2194A - Details on mating procedure:
- - M/F ratio per cage: 1 to 1
- Length of cohabitation: 15 day
- Proof of pregnancy: Vaginal plug or sperm in vaginal smear referred to as day 0 of pregnancy; after 10 days of unsuccessful pairing replacement of first male by another male with proven fertility.
- Further matings after two unsuccessful attempts: No
- After successful mating each pregnant female was caged (how): Individually in nesting box - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Top, middle, and bottom samples of a 20 and 200 mg/mL dose formulation were tested to determine homogeneity. All samples were within 6% of the nominal concentration indicating that the dose formulations were homogeneous. Stability was tested on the 20 and 200 mg/mL dose formulation stored in the refrigerator and sampled at 3, 8, 15, and 29 days. The dose formulations were found to be stable under these conditions with all samples within 7% of the nominal value. All dose formulations were tested during weeks 1, 3, and 7 and were all found to be within 4% of the nominal concentration.
- Duration of treatment / exposure:
- Males: 28 days prior to mating and until the day prior to euthanasia (43 to 47 days)
Females (breeding): 14 days prior to mating, during mating, gestation, and lactation, and until the day prior to euthanasia (42 to 51 days) - Frequency of treatment:
- Daily
- Details on study schedule:
- There were no F1 parental animals.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 100, 500, 1000 mg/kg/day
Basis:
actual ingested
- No. of animals per sex per dose:
- 12 animals per sex per dose
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: Doses were selected bases on a range-finding study.
- Positive control:
- None
Examinations
- Parental animals: Observations and examinations:
- CAGE SIDE OBSERVATIONS: No
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: Once daily except mortality which was checked twice a day.
BODY WEIGHT: Yes
- Time schedule for examinations: Weekly and in pregnant rats on day 0, 7, 14, and 20 of gestation and day 1 and 4 of lactation
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: No
CLINICAL CHEMISTRY: No
URINALYSIS: No
- Oestrous cyclicity (parental animals):
- Not examined
- Sperm parameters (parental animals):
- Parameters examined in P male parental generations: Testis weight and epididymis weight
- Litter observations:
- STANDARDISATION OF LITTERS
- Performed on day 4 postpartum: No
PARAMETERS EXAMINED
The following parameters were examined in F1: number and sex of pups, stillbirths, live births, postnatal mortality, presence of gross anomalies, weight gain, physical or behavioural abnormalities
GROSS EXAMINATION OF DEAD PUPS:
yes, for external and internal abnormalities; possible cause of death was not determined for pups born or found dead. - Postmortem examinations (parental animals):
- SACRIFICE
- Male animals: All surviving animals on day 47.
- Maternal animals: All surviving animals on lactation day 4.
GROSS NECROPSY
- Gross necropsy consisted of external and internal examinations including the cervical, thoracic, and abdominal viscera.
HISTOPATHOLOGY / ORGAN WEIGHTS: Histopathology and organ weights were only performed in males and nonbreed females. Organs examined in 5 randomly selected males and females are marked in Table 2. Organs weighed are marked twice. Organs were collected from breed females, but were stated to be collected for possible future examination. - Postmortem examinations (offspring):
- SACRIFICE
- The F1 offspring were sacrificed at 4 days of age; these animals were subjected to postmortem examinations (macroscopic) and as follows:
GROSS NECROPSY
- Gross necropsy consisted of external and internal examinations including the cervical, thoracic, and abdominal viscera. - Statistics:
- A one-way ANOVA followed by a Dunnett's or modified Dunnett's test was used for continuous data. Chi-square test was used for count data. Two-tailed analyses were used with p<0.05.
- Reproductive indices:
- Fertility, gestation, parturition, and lactation
- Offspring viability indices:
- Live and dead pups, number of litters with live offspring, mean live litter size, male to female ratio, and the number of survivors
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Other effects:
- not specified
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not examined
- Reproductive function: sperm measures:
- not examined
- Reproductive performance:
- no effects observed
Details on results (P0)
BODY WEIGHT AND FOOD CONSUMPTION (PARENTAL ANIMALS): Body weight was not affected by treatment. There were sporadic changes in food consumption, but since the results are not related to changes in body weight it is not considered related to treatment.
REPRODUCTIVE PERFORMANCE (PARENTAL ANIMALS): There were no changes in reproductive performance.
ORGAN WEIGHTS (PARENTAL ANIMALS): There were no differences in reproductive organ weights.
GROSS PATHOLOGY (PARENTAL ANIMALS): Gross pathology did not indicate any differences in reproduction or the reproductive organs.
HISTOPATHOLOGY (PARENTAL ANIMALS): Histopathology in the males did not indicate any differences in the reproductive organs. Histopathology in nonbreed females did not indicate any affect on reproductive organs. Histopathology was not conducted on the breeding females.
OTHER FINDINGS (PARENTAL ANIMALS)
Effect levels (P0)
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- other: Overall effects
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not examined
- Mortality / viability:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Sexual maturation:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings:
- not examined
Details on results (F1)
BODY WEIGHT (OFFSPRING): There were no effects on body weight at birth or lactation day 4.
GROSS PATHOLOGY (OFFSPRING): There were no treatment-related effects on gross pathology.
Effect levels (F1)
- Dose descriptor:
- NOEL
- Generation:
- F1
- Effect level:
- 1 000 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- other: Live birth index, pup weight, sex ratio, survival index, viability index, no gross abnormalities
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- A reproductive/developmental NOEL of 1000 mg/kg/day was established for both males and females.
- Executive summary:
In this screening for reproductive/developmental toxicity study, 1 -tetradecene was administered via gavage to twelve Sprague-Dawley Crl:CDBR VAF/Plus rats/sex/dose at doses of 0, 100, 500, or 1000 mg/kg/day (5 mL/kg of 0, 20, 100, or 200 mg/mL solution in corn oil). The test material was composed of equal amounts of Neodene 14 alpha olefin, alpha olefin C14 1 -tetradecene, and 1 -tetradecene Gulftene 14, which were obtained from different sources. Males were treated for 43 to 47 days beginning 28 days prior to mating and females were treated for 42 to 51 days beginning 14 days prior to mating through lactation day 4.
No reproductive or developmental effects were observed. There were clinical signs noted in 500 and 1000 mg/kg/day females, but they were unrelated to reproduction. There was no LOEL for this study. The NOEL for reproductive and developmental toxicity was 1000 mg/kg/day.
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